Volume-3 Issue-3, April 2023 – International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR)

F4027103623

IJAPSR Journal — Wed, 23 Jul 2025 07:12:34 +0000

The International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) has ISSN 2582-7618 (online), open-access, peer-reviewed, periodical bi-monthly international journal, which is published by Lattice Science Publication (LSP) in February, April, June, August, October and December. The journal aims to publish high-quality peer–reviewed original articles in the area of Pharmaceutical Sciences that covers Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Medical Physiology, Pharmaceutical Chemistry, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest. #Pharmaceutical Technology #Pharmaceutics #Biopharmaceutics #Pharmacokinetics #Medical Physiology Pharmaceutical Chemistry #Medicinal Chemistry #Computational Chemistry and Molecular Drug Design #Pharmacognosy and Phytochemistry #Pharmacology #Pharmaceutical Analysis #Pharmacy Practice #Clinical and Hospital Pharmacy #Cell Biology #Genomics and Proteomics #Pharmacogenomics #Bioinformatics #Biotechnology of Pharmaceutical Interest #PhD #Academic #Scopus #SCI #LatticeScience #Springer, #ScienceDirect #IEEE #Mendeley #Research #Scholarship #UGC #SSRN #LatticeScience #ESCI #Science #Journal #Conference #SSRN #PubLons

Formulation and Evaluation of Imeglimin Hydrochloride Immediate Release Tablet
Kamlesh Singh Bora¹, Archana Rautela², Reetu Papola³, Praveen Kumar Ashok⁴

¹Kamlesh Singh Bora Department of Pharmaceutics, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttarakhand, India.

²Archana Rautela, Department of Pharmaceutics, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttarakhand, India.

³Reetu Papola, Department of Pharmaceutics, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttarakhand, India.

⁴Praveen Kumar Ashok, Department of Pharmaceutics, Gyani Inder Singh Institute of Professional Studies, Dehradun, Uttarakhand, India.

Open Access | Editorial and Publishing Policies | Cite | Indexing and Abstracting
© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: Imeglimin hydrochloride, an oral drug that oversees type 2 diabetes, brings down blood glucose levels. Among other impacts, it also supports mitochondrial DNA and movement while reducing the production of reactive oxygen species (ROS). Imeglimin tablets with a quick delivery recipe are presently being created and tried frequently. Tests were conducted using super-disintegrants, such as Croscarmellose sodium, and the amount of PVPK-30 was adjusted to reduce the disintegration time further. Microcrystalline. The diluent in the definition preliminaries was cellulose, the folio was polyvinylpyrrolidone (K30), and the Glidant was colloidal silicon dioxide. Using the USP Device II (Paddle) at a temperature of 37°C ± 0.5°C and a speed of 50 rpm, the in vitro drug release was studied. Hydrochloric acid, 0.1 N, was utilised as the dissolving agent. For preliminaries F1 and F6, the level of the drug administered at different times was determined using UV technology. The review’s findings revealed that Preliminary F6 provided the best detailing. Every estimation was within the permitted range specified by the Pharmacopoeial Details. The actual properties of different tablets, including hardness, thickness, weight variation, friability, percentage drug content, and in vitro drug release, were scrutinised.

Keywords: Type 2 diabetes, Wet granulation, In vitro dissolution, Disintegration, and Pre-formulation, Imeglimin hydrochloride.
Scope of the Article: Pharmaceutical Technology

Download PDF

The post F4027103623 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).

C403804030424

IJAPSR Journal — Wed, 23 Jul 2025 05:57:46 +0000

Management of Hypertension: Clinical Relevance and Perspective
Rashi Bandey¹, Anupa Bhagat², Hari Prasad Sonwani³, Aaftab⁴, Pragati⁵

¹Rashi Bandey, Department of Pharmacology, Apollo College of Pharmacy, Anjora Durg (C.G), India.

²Anupa Bhagat, Department of Pharmacology, Apollo College of Pharmacy, Anjora Durg (C.G.), India.

³Hari Prasad Sonwani, Department of Pharmacology, Apollo College of Pharmacy, Anjora Durg (C.G), India.

⁴Aaftab, Department of Pharmacology, Apollo College of Pharmacy, Anjora Durg (C.G), India.

⁵Pragati, Department of Pharmacology, Apollo College of Pharmacy, Anjora Durg (C.G), India.

Abstract: Hypertension, sometimes referred to as the “silent killer,” is a serious and global public health issue. This review article provides an in-depth examination of the epidemiology, pathophysiology, diagnosis, complications, and therapeutic approaches related to hypertension. We investigate the prevalence of hypertension in various demographic groups, as well as the underlying mechanisms, risk factors, and effects it has on different organ systems. We also review the importance of a precise diagnosis, including methods for measuring blood pressure and established diagnostic standards. We also explore the complex field of hypertension management, which encompasses pharmaceutical interventions, lifestyle modifications, and emerging therapeutic approaches. The purpose of this thorough review is to help healthcare practitioners better understand and treat hypertension. Management of hypertension typically involves a combination of lifestyle modifications and medication. Lifestyle changes may include adopting a healthy diet (such as the DASH diet), regular exercise, maintaining a healthy weight, reducing sodium intake, limiting alcohol consumption, and managing stress. Medications, such as diuretics, ACE inhibitors, angiotensin II receptor blockers (ARBs), beta-blockers, calcium channel blockers, and others, may be prescribed depending on the individual’s blood pressure levels and other medical conditions. Individuals with hypertension need to work closely with their healthcare provider to develop a personalised treatment plan. Hypertension is a significant and costly public health problem. It is a major, but modifiable, contributor to the development of cardiovascular disease. Randomized controlled trials have shown that controlling hypertension reduces the risk of stroke, coronary artery disease, congestive heart failure, end-stage renal disease, peripheral vascular disease, as well as overall mortality. The risk of developing these hypertension-related complications is continuous, starting at a blood pressure level as low as 115/75 mm Hg. Despite the inherent health risks associated with uncontrolled hypertension, elevated blood pressure remains inadequately treated in the majority of patients. This article reviews guidelines for optimal evaluation of hypertension and current therapeutic options available to combat this common yet pervasive disease.

Keywords: Hypertension, High Blood Pressure, Epidemiology, Aetiology, Pathophysiology, Complications, Diagnosis, Management Strategies.
Scope of the Article: Pharmacology

Download PDF

The post C403804030424 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).

A4037124123

IJAPSR Journal — Wed, 23 Jul 2025 05:50:09 +0000

Synthetic Vs Natural Nicotine: Investigation in the Indian Contextr
Stuti Menon

Stuti Menon, Department of Chemistry, Navrachana International School, Vadodara (Gujarat), India.

Abstract: The objective of this study is to ascertain the enantiomeric composition and purity of synthetic nicotine samples in India, evaluating whether the surge in synthetic nicotine’s popularity is paralleled by adequate knowledge of its pharmacological and toxicological effects. This research employs established US Pharmacopoeia [1] methods to analyse synthetic nicotine (resolved to the S-isomer) against Tobacco-Derived Natural Nicotine (TDN). Polarimetry and Gas Chromatography are the primary techniques utilized to determine the enantiomeric ratio and purity of nicotine in the samples. The study finds that Synthetic Nicotine, when resolved to the S-isomer, exhibits characteristics closely similar to TDN. Conversely, the racemic mixture of Synthetic Nicotine presents a balanced ratio of R and S isomers, as evidenced by the absence of optical rotation. These results suggest that Synthetic Nicotine has been accurately resolved to match the enantiomeric purity of natural nicotine. This research has implications for manufacturers, users, and policymakers. For manufacturers, it emphasizes the necessity for precise production techniques. For users, particularly in India, it emphasizes the importance of awareness about the contents of nicotine products. For policymakers, the study signals the urgent need for regulatory frameworks to manage the production and sale of synthetic nicotine, ensuring public health safety. This research fills a critical gap in the existing literature by providing empirical data on the enantiomeric composition of synthetic nicotine within the Indian context, a largely under-researched area. The findings and methodologies offer a valuable reference point for further studies and regulatory assessments.

Keywords: Synthetic Nicotine, Enantiomeric Purity, Tobacco Derived Nicotine, Pharmacological Effects, India
Scope of the Article: Medicinal Chemistry

Download PDF

The post A4037124123 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).

A4034124123

IJAPSR Journal — Wed, 23 Jul 2025 05:45:48 +0000

Recent Therapeutic Status of Photodynamic Therapy for the Treatment and Diagnosis of Cancer
Pratikeswar Panda

Pratikeswar Panda, Department of Pharmaceutics, Siksha ‘O’ Anusandhan University, Bhubaneswar (Odisha), India.

Abstract: Photodynamic therapy (PDT) is a cancer and infectious illness therapy that uses reactive oxygen species (ROS) produced by light and a photosensitizer to cause cellular damage. In this review, we focus on recent advancements of PDT and how they may be manipulated to improve clinical outcome in cancer patients. PDT has demonstrated a promising translation into cancer therapeutics when combined with chemotherapy, PTT and immunotherapy. Additionally, PDT is being used to treat bacterial infections and combat antibiotic resistance. We have now covered the new paths PDT is taking in the treatment of infectious and cancerous disorders. In summary, we believe that advancements may significantly impact the development of PDT for cancer treatment using nanomaterials and thoughtful design.

Keywords: Photodynamic Therapy (PDT), Oxygen Species (ROS), Translation, Chemotherapy, Immunotherapy, Antibiotic Resistance.
Scope of the Article: Pharmacy Practice

Download PDF

The post A4034124123 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).