International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR)

A4036124123

IJAPSR Journal — Mon, 01 Jan 2024 05:34:22 +0000

The International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) has ISSN 2582-7618 (online), open-access, peer-reviewed, periodical bi-monthly international journal, which is published by Lattice Science Publication (LSP) in February, April, June, August, October and December. The journal aims to publish high-quality peer–reviewed original articles in the area of Pharmaceutical Sciences that covers Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Medical Physiology, Pharmaceutical Chemistry, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest. #Pharmaceutical Technology #Pharmaceutics #Biopharmaceutics #Pharmacokinetics #Medical Physiology Pharmaceutical Chemistry #Medicinal Chemistry #Computational Chemistry and Molecular Drug Design #Pharmacognosy and Phytochemistry #Pharmacology #Pharmaceutical Analysis #Pharmacy Practice #Clinical and Hospital Pharmacy #Cell Biology #Genomics and Proteomics #Pharmacogenomics #Bioinformatics #Biotechnology of Pharmaceutical Interest #PhD #Academic #Scopus #SCI #LatticeScience #Springer, #ScienceDirect #IEEE #Mendeley #Research #Scholarship #UGC #SSRN #LatticeScience #ESCI #Science #Journal #Conference #SSRN #PubLons

A Review Study of Proline-Derived Paclitaxel as Treatment Anti Cancers
Neamah Omar Alshhada¹, Haya Asmail Alhamdo², Nasser Thallaj³

¹Neamah Omar Alshhada, Student, Department of Pharmaceutical chemistry and Drug Quality Control, Faculty of Pharmacy, Al-Rachid Privet University, Damascus, Syria.

²Haya Asmail Alhamdo, Student, Department of Pharmaceutical Chemistry and Drug Quality control, Faculty of Pharmacy, Al-Rachid Privet University, Damascus, Syria.

³Prof. Nasser Thallaj, Department of Pharmaceutical Cchemistry and Drug Quality Control, Faculty of Pharmacy, Al-Rachid Privet University, Damascus, Syria.

Open Access | Editorial and Publishing Policies | Cite | Zenodo | Indexing and Abstracting
© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: Of the numerous helpful specialists utilized in oncology, paclitaxel (Taxol) has likely pulled in the foremost intrigued. It is utilized clinically to treat ovarian, breast and lung cancer. It acts as a mitotic axle harm by advancing the get together of tubulin into microtubules and stabilizing the coming about polymer. It was initially extricated from Pacific yew (Taxus Brevifolia) and gotten by semi-synthesis of 10-deacetylbaccatin III, but is presently created by a biotechnological prepare of plant cell maturation. Paclitaxel encompasses a complex chemical structure based on a tetracyclic taxane. To recognize paclitaxel mimetics, a handle of supplanting the taxane spine with a less difficult chemical structure was carried out. The recognizable proof of a proline-derived chemical part (fragmentbased medicate plan) through atomic modeling ponders driven to the advancement of a unused arrangement of paclitaxel imitates. In the interim, substitution of the taxane spine with a cyclic peptide structure utilizing proline subsidiaries was carried out. Atomic modeling considers, union and natural assessment o f paclitaxel mimetics are displayed.

Keywords: Paclitaxel, Taxol, Tubulin, Microtubule, Cancer, Proline, Mimic, Fragment, Cyclotriproline.
Scope of the Article: Pharmaceutical Analysis

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A4033124123

IJAPSR Journal — Wed, 20 Dec 2023 09:06:43 +0000

Analysis of Medicinal Plants and Traditional Knowledge Development in Ethiopia
Bekele Kindie

Bekele Kindie, Department of Plant Genetics, Ethiopia Biodiversity Institute Harar Biodiversity, Addis Ababa, Amhara, Ethiopia.

Abstract: The review conducted in Ethiopia has revealed a rich diversity of medicinal plant species and traditional knowledge that play a significant role in the management of various human and livestock diseases. Medicinal plants are widely used by communities, particularly rural communities, to treat various human and livestock ailments. Medicinal plants are also crucial for the development of modern medicine. Traditional knowledge refers to the collective knowledge accumulated by communities within their respective cultures, beliefs, and experiences. Different parts of medicinal plants are used in traditional remedies to treat humans and livestock. Traditional knowledge and medicinal plants are critically threatened and in danger of extinction due to overgrazing, charcoal production, deforestation, urbanisation, agricultural expansion, and firewood collection. Traditional medicinal plants and associated knowledge can be conserved using either in situ or ex-situ conservation methods. Therefore, create awareness among the local people about the use of medicinal plants and the associated knowledge to ensure sustainable harvesting of medicinal plants. Conducting ethnobotanical research and documenting medicinal plants, as well as indigenous knowledge, is essential for conservation.

Keywords: Ethnobotany, Indigenous Knowledge, Threats, Plants, Ethiopia
Scope of the Article: Pharmaceutical Analysis

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A4035124123

IJAPSR Journal — Wed, 20 Dec 2023 09:01:59 +0000

Application of Hyperthermia for Cancer Treatment: Various Techniques and Recent Advancement
Pratikeswar Panda

Pratikeswar Panda, Department of Pharmaceutics, Siksha ‘O’ Anusandhan University, Bhubaneswar, India.

Abstract: Cancer is a disease characterised by uncontrollable cell division in a specific area of the body. It is a leading cause of death, and its prevalence is increasing. There are numerous techniques and protocols employed, including as chemotherapy, radiography, surgical tumor removal, etc. However, these procedures have several adverse side effects that cause excruciating pain and intense anxiety in the patients. Over the past few decades, it has become increasingly challenging to discover new cancer-fighting strategies. One of the best cancer treatment choices is hyperthermia, an ancient form of therapy that offers fresh hope when paired with engineering methods. This study examines the crucial data for coupling various engineering techniques with hyperthermia, carefully organised according to the methods used, such as hyperthermic perfusion, frequency enhancers, ultrasonic hyperthermia, external radio-frequency devices, microwave hyperthermia, and the use of a catheter to heat the target area before injecting superparamagnetic and magnetic nanoparticles.

Keywords: Cancer, Hyperthermia, Ultrasonic, Radio Frequency Devices, Hyperthermic Perfusion, Microwave, Magnetic Nanoparticles
Scope of the Article: Pharmaceutical Technology

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F4029103623

IJAPSR Journal — Wed, 20 Dec 2023 08:55:12 +0000

Tacrolimus Interaction with Azole Antifungals in Kidney Transplant Recipients: Is Fluconazole or Clotrimazole a Worse Offender?
Jane Revollo¹, Vinaya Rao², Amy Krauss³, Alison L. Apple R. Ph.⁴, Benjamin Duhart⁵

¹Jane Revello, Pharm.D., CPP, Department of Pharmacy, Atrium Health Carolinas Medical Center, Charlotte, NC, United States of America (USA).

²Vinaya Rao, MD, Department of Nephrology, Medical University of South Carolina, Charleston, SC, United States of America (USA).

³Alison Apple, RPh, MS, Department of Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA, United States of America (USA).

⁴Amy Krauss, PharmD, BCPS, Department of Pharmacy, Gritman Medical Center, Moscow, ID, United States of America (USA).

⁵Benjamin Duhart, Jr., MS, PharmD, Department of Clinical Pharmacy and Translational Research, University of Tennessee Health Science Center College of Pharmacy, Memphis, TN, United States of America (USA).

Abstract: The utilization of rabbit ant thymocyte globulin induction with tacrolimus-based maintenance immunosuppression may increase the risk for opportunistic fungal infections, particularly oral-esophageal candidiasis. Both are commonly prescribed for deceased donor kidney transplant recipients Tacrolimus (TAC), a calcineurin inhibitor, is metabolized hepatically by cytochrome P450 3A4/5 enzymes. Due to this, a drug interaction can occur with TAC and either fluconazole (FCZ) or clotrimazole (CTMZ). Both are commonly used for antifungal prophylaxis. While both FCZ and CTMZ inhibit CYP3A4/5, systemic absorption of CTMZ is minimal, theoretically limiting the interaction with TAC and reducing the need for dose readjustments. Medical records for adult patients receiving a renal transplant between March 2009 and September 2011 were retrospectively reviewed for TAC dose adjustments following discontinuation of the antifungal agent required to maintain therapeutic TAC blood levels. The change in TAC dose: trough ratio 4-8 weeks after azole discontinuation was greater in patients receiving FCZ compared to CTMZ (FCZ +92.9% vs CTMZ +43.4%, p=0.004). In addition, the proportion of patients requiring a≥30% TAC dose increase was 70% with FCZ versus 45% with CTMZ (p = 0.006). The choice of antifungal also did not affect the number of sub-therapeutic TAC levels, the number of patients with sub-therapeutic levels pre- or post-discontinuation, or the incidence of biopsy-proven allograft rejection.

Keywords: Tacrolimus, Fluconazole, Clotrimazole, Kidney transplant
Scope of the Article: Intelligence Applications

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A4030124123

IJAPSR Journal — Wed, 20 Dec 2023 07:55:52 +0000

Phytochemical and Biological Activity of Rice Bran: A Review
Dinesh Kumar Chauhan¹, Neeraj Sharma²

¹Mr. Dinesh Kumar Chauhan, HOD, Department of Pharmacy, Bhagwant University, Sikar Road, Ajmer (Rajasthan) India.

²Dr. Neeraj Sharma, Department of Pharmacy, Bhagwant University, Sikar Road, Ajmer (Rajasthan) India.

Abstract: Rice is the most commonly consumed food by human beings all over the world. The various countries easily cultivate it. Rice is an annual plant. It grows in an area with a rich supply of water. The height of rice bran depends on the depth of water. Approximately 13,500 years ago, Oryza sativa was the first rice plant cultivated in the Yangtze River basin. Rice bran is a milling product of rice. Various studies have shown that rice bran contains a range of phytochemical constituents. This constituent consists of vitamin E, thiamine, Niacin, and minerals, Tocotrienol, oryzanol, tocopherol, gallic acid, vanillic acid, etc and nutritional components like carbohydrates, protein, fat and dietary fiber, vitamins, and minerals, etc. rice valuable bran for health and contain antioxidant property due to presence of tocopherol, tocotrinol and gama-oryzanols. Traditionally, rice bran has been used as a treatment for various diseases, including diabetes, cancer, liver disease, and heart disease. It is also used as a skincare product. Due to the presence of tocopherol, Tocotrienol, and gama-oryzanols rice bran is used for the treatment of various diseases or disorders like cancer, hypertension, lowering serum cholesterol, skin-related problems, insulin sensitivity, etc. during various studies shown by multiple scientists that rice bran has a rich source of a nutritional constituent, medicinal value as well as neutraceutical value. Various food industries use rice bran as a nutraceutical ingredient. Rice bran is a rich source of gammaoryzanol. Hence, it is used to improve disease conditions. Several studies have demonstrated the biological effects of rice bran in improving hypertension, diabetes, and hypercholesterolemia, while also lowering cholesterol levels and reducing the risk of various diseases, including cancer and skin problems.

Keywords: Rice bran, Oryza Sativa, Vitamins, Minerals, Gama-Oryzanols, Tocotrienol.
Scope of the Article: Pharmacognosy and Phytochemistry

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