Volume-4 Issue-6, October 2024 – International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR)

F405604061024

IJAPSR Journal — Sat, 26 Oct 2024 03:56:10 +0000

The International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) has ISSN 2582-7618 (online), open-access, peer-reviewed, periodical bi-monthly international journal, which is published by Lattice Science Publication (LSP) in February, April, June, August, October and December. The journal aims to publish high-quality peer–reviewed original articles in the area of Pharmaceutical Sciences that covers Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Medical Physiology, Pharmaceutical Chemistry, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest. #Pharmaceutical Technology #Pharmaceutics #Biopharmaceutics #Pharmacokinetics #Medical Physiology Pharmaceutical Chemistry #Medicinal Chemistry #Computational Chemistry and Molecular Drug Design #Pharmacognosy and Phytochemistry #Pharmacology #Pharmaceutical Analysis #Pharmacy Practice #Clinical and Hospital Pharmacy #Cell Biology #Genomics and Proteomics #Pharmacogenomics #Bioinformatics #Biotechnology of Pharmaceutical Interest #PhD #Academic #Scopus #SCI #LatticeScience #Springer, #ScienceDirect #IEEE #Mendeley #Research #Scholarship #UGC #SSRN #LatticeScience #ESCI #Science #Journal #Conference #SSRN #PubLons

Clinical and Demographic Profile of Syrian Patients with Malignant Glioma: A Six-Month Retrospective Analysis
Rama Ibrahim¹, Zein Al-Abideen Douba², Reema Khaddam³, Haidar Ibrahim⁴, Bassam Saad⁵

¹Dr. Rama Ibrahim, Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al-Sham Private University (ASPU), Lattakia, Syria.

²Zein Al-Abideen Douba, Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria.

³Reema Khaddam, Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al-Sham Private University (ASPU), Lattakia, Syria.

⁴Haidar Ibrahim, Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al-Sham Private University (ASPU), Lattakia, Syria.

⁵Dr. Bassam Saad, Department of Oncology, Faculty of Medicine, Tishreen University, Lattakia, Syria.

Open Access | Editorial and Publishing Policies | Cite | Zenodo | OJS | Indexing and Abstracting
© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: This study presents a retrospective analysis of glioblastoma cases admitted to Tishreen University Hospital in Lattakia, Syria, between February and August 2024. The study examines several potential risk factors, including age, sex, genetic predispositions, and lifestyle factors such as smoking and alcohol consumption. It also discusses the most commonly encountered tumour grade and the prevalence of various neurological symptoms, as well as treatment outcomes. A total of 30 glioblastomas were enrolled in this study, 63% of which were males, and the highest age incidence was between 40 and 50 years. Only 6% had a family history of glioblastoma, and 66% of the patients were smokers. Memory disorders, visual impairments, and headaches were common symptoms, with 100% of the patients reporting nausea and vomiting. Glioblastoma diagnosis was primarily established through MRI with contrast (76%), and the predominant treatment modality was surgery combined with radiotherapy and chemotherapy (80%). Posttreatment relapse occurred in 26% of the patients, with a median remission period of four months. These findings provide important insights into the clinical characteristics and treatment outcomes of glioblastoma patients in this region.

Keywords: Glioblastoma, Clinical Characteristics, Neurological Symptoms, Risk factors, Treatment Outcomes.
Scope of the Article: Hospital Pharmacy

Download PDF

The post F405604061024 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).

F405504061024

IJAPSR Journal — Sat, 26 Oct 2024 03:49:29 +0000

Advancements in Inverse-Electron-Demand Diels–Alder Cycloaddition of 2-Pyrones: Mechanisms, Methodologies
Nasser Thallaj

Prof. Dr. Nasser Thallaj, Pharmaceutical Chemistry and Drug Quality Control Department, Faculty of Pharmacy, Al-Rachid Privet University, Damascus (Syria), West Asia.

Abstract: The Diels-Alder (DA) cycloaddition is well-known for its effectiveness in synthesizing natural products and multifunctional materials. This article explicitly explores the inverse-electron-demand Diels-Alder (IEDDA) cycloaddition involving 2-pyrones, which exhibit ambiphilic properties due to their unique electronic characteristics. We investigate the mechanisms underlying IEDDA, with a focus on how electrondonating and electron-withdrawing substituents influence reactivity and product selectivity. Various methodologies are reviewed, encompassing non-catalytic and catalytic approaches. Special attention is given to advancements in microwave-assisted techniques and high-pressure conditions, which enhance both reaction efficiency and selectivity. Additionally, the synthesis of chiral bridged bicyclic lactones from substituted 2-pyrones is examined, illustrating their versatility in organic synthesis. This review highlights the importance of IEDDA cycloaddition in developing innovative synthetic routes for constructing complex molecular structures.

Keywords: Diels–Alder Cycloaddition; Inverse-Electron-Demand; 2-Pyrones; Electrophilic Dienes; Microwave-Assisted Synthesis; Chiral Bicyclic Lactones; Reaction Mechanisms.
Scope of the Article: Pharmaceutical Chemistry

Download PDF

The post F405504061024 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).

F405404061024

IJAPSR Journal — Sat, 26 Oct 2024 03:45:15 +0000

Conductive Nanocomposites Based on Graphene and Natural Polymers
Nasser Thallaj

Prof. Dr. Nasser Thallaj, Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmacy, Al-Rachid Privet University, Damascus (Syria), West Asia.

Abstract: This thesis focuses on the development of conductive nanocomposite materials based on graphene and natural polymers, including cellulose and chitosan. Graphene, a single layer of carbon atoms arranged in a honeycomb lattice, exhibits exceptional electrical, mechanical, and thermal properties, making it an attractive filler for polymer composites. However, the challenge lies in effectively dispersing graphene sheets within polymer matrices. The work presented explores new strategies for grafting polysaccharide chains onto oxidized graphite (graphene oxide) to improve its compatibility and dispersion in cellulose and chitosan matrices. The resulting composites were doped with gold or nickel nanoparticles to enhance their electrical and catalytic properties further. Detailed characterization techniques, including spectroscopic and microscopic methods, were employed to analyze the structure, morphology, and properties of the developed nanocomposites. The thesis is organized into three main parts: 1) a literature review on graphene, polysaccharides, and their biocomposites; 2) a description of the experimental materials and methods; and 3) a scientific discussion of the results, presented in the form of three research publications. The findings demonstrate the successful synthesis of conductive nanocomposites with improved compatibility and performance, opening up new avenues for the application of these sustainable and multifunctional materials in areas such as electronics, catalysis, and electromagnetic shielding.

Keywords: Conductive Nanocomposites; Graphene; Natural Polymers (Cellulose and Chitosan); Polysaccharide Grafting; Gold Nanoparticles; Nickel Nanoparticles; Electrical Properties; Catalytic Properties.
Scope of the Article: Pharmaceutical Chemistry

Download PDF

The post F405404061024 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).

F405304061024

IJAPSR Journal — Sat, 26 Oct 2024 03:41:01 +0000

Assessment of Knowledge About High Blood Pressure Among Syrians
Ritta Nouira¹, Ayat Abbood²

¹Ritta Nouira, Department of Pharmacy, Tishreen University, Latakia, Syria.

²Prof. Ayat Abbood, Department of Medicinal Chemistry, Tishreen University, Latakia, Syria.

Abstract: Hypertension, often referred to as the silent killer, is a prevalent health issue that impacts more than a billion individuals worldwide. The purpose of this study was to investigate the understanding of hypertension among Syrian individuals. 104 individuals filled out surveys. The surveyed group consisted of 64.4% females. 28.8% of the participants in the study were between the ages of 46 and 60. More than half of the participants had a study or a work related to the medical field. The participants demonstrated good medication adherence, as evidenced by a high score in accurate responses to questions regarding medication compliance. Most participants were familiar with the normal values of blood pressure levels and were optimistic about the possibility of treating the condition. A good percentage of individuals surveyed stated that smoking and obesity are contributing factors to developing high blood pressure. Most participants believed that consuming fatty foods raises plasma cholesterol levels. Participants had a good overall understanding of high blood pressure. However, they still need improvement in medical information about high blood pressure to enhance compliance with treatments.

Keywords: Diclofenac, Syria, usage, Practice, Survey.
Scope of the Article: Pharmaceutical Technology

Download PDF

The post F405304061024 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).

F405204061024

IJAPSR Journal — Fri, 25 Oct 2024 13:02:17 +0000

Assessment of use and Awareness of Diclofenac in Syria
Reem Al-Saroukhy¹, Reem Al-Kara², Reem Habib³, Ayat Abbood⁴

¹Reem Al-Saroukhy, Student, Faculty of Pharmacy, University of Tishreen, Latakia, Syria.

²Reem Al-Kara, Student, Faculty of Pharmacy, University of Tishreen, Latakia, Syria.

³Reem Habib, Student, Faculty of Pharmacy, University of Tishreen, Latakia, Syria.

⁴Prof. Ayat Abbood, Department of Medicinal Chemistry and Quality Control, Faculty of Pharmacy, University of Tishreen, Latakia, Syria.

Abstract: Diclofenac, known as diclone in Syria, is the most widely used drug in multiple medical conditions. This research was conducted to assess the use and awareness of diclofenac in Syria through a survey. Six hundred one responses were included in this research. Most participants were female (67.7%), between the ages of 18 and 30 years (82.9%), and did not have a chronic disease (86.3%). More than half of the participants were university students (53.4%). A high proportion of the participants had a university education level (87.7%). The most used dosage form for diclofenac was tablets among participants (70.9%). 43.8% chose 50mg as the dose of diclofenac. Most participants improved after using diclofenac (73.7%). Participants were satisfied after diclofenac treatment (66.56%). Most had no side effects after treatment with diclofenac (79.5%). 81.3% of the participants who experienced side effects suffered from stomach pain. Fortunately, 84.4% of the participants did not use the injection combining diclofenac with cortisone and an antibiotic. 56.38% used this combination to treat respiratory infections. A minority of the participants experienced allergic reactions after taking this medication (4%). More than two-thirds of the participants (65.9%) plan to continue using diclofenac for pain management in the future. Additionally, 77.9% of the participants used diclofenac without a prescription. Most participants used this medicine after a meal (82%). 36.6% of the participants reported that half an hour was the onset of diclofenac. The participants reported an action duration of 6 hours (24.5%) and 8 hours (31%). This study confirmed the high use of diclofenac among the Syrians. A good level of awareness was observed among the surveyed participants.

Keywords: Diclofenac, Syria, usage, Practice, Survey.
Scope of the Article: Pharmaceutics

Download PDF

The post F405204061024 appeared first on International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR).

Volume-4 Issue-6, October 2024 – International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR)

F405604061024

Share this entry

F405504061024

Share this entry

F405404061024

Share this entry

F405304061024

Share this entry

F405204061024

Share this entry