Volume-5 Issue-1, December 2024 – International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR)

B406605020225

IJAPSR Journal — Thu, 26 Dec 2024 12:16:19 +0000

The International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR) has ISSN 2582-7618 (online), open-access, peer-reviewed, periodical bi-monthly international journal, which is published by Lattice Science Publication (LSP) in February, April, June, August, October and December. The journal aims to publish high-quality peer–reviewed original articles in the area of Pharmaceutical Sciences that covers Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Medical Physiology, Pharmaceutical Chemistry, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest. #Pharmaceutical Technology #Pharmaceutics #Biopharmaceutics #Pharmacokinetics #Medical Physiology Pharmaceutical Chemistry #Medicinal Chemistry #Computational Chemistry and Molecular Drug Design #Pharmacognosy and Phytochemistry #Pharmacology #Pharmaceutical Analysis #Pharmacy Practice #Clinical and Hospital Pharmacy #Cell Biology #Genomics and Proteomics #Pharmacogenomics #Bioinformatics #Biotechnology of Pharmaceutical Interest #PhD #Academic #Scopus #SCI #LatticeScience #Springer, #ScienceDirect #IEEE #Mendeley #Research #Scholarship #UGC #SSRN #LatticeScience #ESCI #Science #Journal #Conference #SSRN #PubLons

Advancing Anemia Screening: Performance of the Aspen Hb Meter Compared to Standard Methods
Ashish Nasa¹, Pankaj Mutreja², Rohtash Bhardwaj³, Pankaj K. Tyagi⁴

¹Dr. Ashish Nasa, Department of Radio-diagnosis, Al-Ameen Medical College & Hospital, Vijaypur (Karnataka), India.

²Pankaj Mutreja, Life Care Hospital (NABH Accredited), Karnal (Haryana), India.

³Rohtash Bhardwaj, Life Care Hospital (NABH Accredited), Karnal (Haryana), India.

⁴Dr. Pankaj K. Tyagi, School of Biotechnology, Noida Institute of Engineering and Technology, Gautam Buddha Nagar (U. P.), India.

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© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: Anemia, a global health concern with significant prevalence in low- and middle-income countries, poses serious challenges for women of reproductive age, particularly in resource-constrained environments. Early and accurate hemoglobin estimation is critical for timely intervention; however, traditional methods like the cyanmethemoglobin assay and automated hematology analyzers are impractical in decentralized settings. This study evaluates the performance of the Aspen Hb meter, a portable, spectrophotometry-based device, against the Serachem SC-60+ auto hematology analyzer. Hemoglobin levels from 1,280 adult females were analyzed, showing a strong correlation (R² = 0.977) and clinically acceptable agreement in Bland-Altman analysis. The Aspen Hb meter achieved a sensitivity of 98.14%, specificity of 95.80%, and accuracy of 97.57%, with minimal diagnostic errors. Its portability, rapid response, and cost-effectiveness highlight its utility in point-of-care diagnostics and public health programs. This device provides a scalable solution for enhancing anaemia screening and management in low-resource settings, particularly in maternal health initiatives.

Keywords: Aspen Hb Meter, Hb estimation, Sensitivity, Specificity, Accuracy.
Scope of the Article: Pharmaceutical Biotechnology

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A406405011224

IJAPSR Journal — Mon, 23 Dec 2024 11:46:30 +0000

Advancements in Antiviral Therapeutics: A Comprehensive Review of Hepatitis C Virus and Novel Flavone Leads
Juan Farhad Alrasho¹, Farhad Khalil Sofi², Nasser Thallaj³

¹Prof. Dr. Nasser Thallaj, Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmacy, Al-Rachid Privet University, Damascus, Syria.

²Juan Farhad Alrasho, Department of Pharmaceutical Chemistry and Drug Quality Control, Faculty of Pharmacy, Al-Rachid Privet University, Damascus, Syria.

³Farhad Khalil Sofi, Department of Pharmaceutical Chemistry and Drug Quality Controlt, Faculty of Pharmacy, Al-Rachid Privet University, Damascus, Syria.

Abstract: This review examines the fundamental characteristics and implications of viruses, with a focus on their classification, structure, and the specific case of the Hepatitis C Virus (HCV). Viruses, nonliving biological entities that rely on host cells for replication, have historically played a pivotal role in understanding infectious diseases. The classification of viruses has undergone significant evolution, resulting in a hierarchical system that categorises them by order, family, genus, and species based on their genomic characteristics and structural features. HCV, a member of the Flaviviridae family, presents a significant global health concern, affecting over 150 million people and causing approximately 500,000 deaths annually. The virus is characterized by its enveloped structure and single-stranded RNA genome, which encodes a polyprotein that is cleaved into functional proteins essential for viral replication and assembly. The epidemiology of HCV reveals regional prevalence variations, with higher rates observed in developing countries. Notably, the virus exhibits considerable genetic diversity, categorized into seven genotypes, each demonstrating different responses to treatment. The natural history of HCV infection is complex, often remaining asymptomatic for extended periods, which complicates diagnosis and treatment initiation. Chronic diseases can lead to severe complications, including liver fibrosis, cirrhosis, and hepatocellular carcinoma. Understanding the mechanisms of HCV entry, replication, and immune evasion is crucial for developing effective antiviral therapies and preventive measures. This review aims to provide a comprehensive overview of the current knowledge surrounding HCV, highlighting the need for ongoing research to understand its biology better and improve therapeutic strategies against this pervasive virus.

Keywords: Hepatitis C Virus; Antiviral Therapy; Flaviviridae; Viral Replication; Genotypes; Directly Acting Antivirals; Immune Evasion; Epidemiology.
Scope of the Article: Pharmaceutical Chemistry

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A406305011224

IJAPSR Journal — Mon, 23 Dec 2024 11:41:26 +0000

Advancements in Pharmaceutical Science: Synthesis and Application of Molecular Cages Integrating N-Heterocyclic Carbenes for Enhanced Stability and Functionality
Nasser Thallaj

Prof. Dr. Nasser Thallaj, Pharmaceutical Chemistry and Drug Quality Control Department, Faculty of Pharmacy, Al-Rachid Privet University, Damascus, Syria.

Abstract: The synthesis of molecular cages to encapsulate chemical entities, such as metal ions, anions, or small molecules, has emerged as a significant area of research in supramolecular chemistry. This article explores the design and construction of various macrocyclic ligands, particularly crown ethers, cryptands, and multi-branched macrocycles, highlighting their unique structural properties and coordination chemistry with transition metals and alkali ions. We delve into the role of N-Heterocyclic Carbenes (NHCs) in enhancing the stability and functionality of these macrocyclic systems. The integration of NHCs into macrocyclic architectures presents opportunities for novel applications in catalysis, photoluminescence, and biomedical fields. By examining the advancements in macrocycle-NHC chemistry, this article underscores the potential of these systems in developing innovative materials with tailored properties for diverse applications.

Keywords: Molecular Cages; Supramolecular Chemistry; Macrocyclic Ligands; N-Heterocyclic Carbenes (NHCs); Crown Ethers; Cryptands; Coordination Chemistry; Photoluminescence.
Scope of the Article: Pharmaceutical Chemistry

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A406105011224

IJAPSR Journal — Mon, 23 Dec 2024 11:37:33 +0000

Insights into Therapeutic Peptides and their Quality Control
Ayat Abbood

Ayat Abbood, Department of Medicinal Chemistry and Quality Control, Faculty of Pharmacy, University of Tishreen, Latakia (Syria), Middle East.

Abstract: Therapeutic peptides have been garnering renewed attention in recent years. The manufacturing of peptides and protein-based drugs is rapidly expanding within the pharmaceutical sector. These compounds may be obtained through solid-phase synthesis or biotechnological methods. Peptides and proteins are delicate molecules that undergo chemical or physical changes such as oxidation of methionine, deamidation of asparagine and glutamine, isomerization, aggregation, and denaturation during production. The alterations could compromise the stability of the drugs, consequently impacting the therapeutic efficacy of the protein or peptide. It is essential to effectively monitor the quality of proteins or peptides to verify the preservation of their biological properties throughout the production process. This review outlines the official guidelines for quality control of peptides manufactured through solid-phase synthesis or genetic engineering. The discussion also covered the frequently utilized separation techniques for evaluating the efficacy of therapeutic peptides.

Keywords: Peptides, Analysis, Quality, Synthesis.
Scope of the Article: Pharmaceutical Technology

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A405905011224

IJAPSR Journal — Mon, 23 Dec 2024 11:33:10 +0000

Statistical Overview of Drug Shortage in Syria
Reem Antakly¹, Fatima Najjar², Ayat Abbood³

¹Reem Antakly, Student, Faculty of Pharmacy, University of Tishreen, (Latakia), Syria.

²Fatima Najjar, Student, Faculty of Pharmacy, University of Tishreen, (Latakia), Syria.

³Ayat Abbood, Department of Medicinal Chemistry and Quality Control, Faculty of Pharmacy, University of Tishreen, (Latakia), Syria.

Abstract: Access to medications is a fundamental aspect of healthcare and vital for human well-being. Medicine shortages are widespread and impact countries across all income levels. This research aimed to monitor the characteristics of drug shortages in Syria through a distributed survey. 76% of the sample were females. 88.9% of the sample were 20-29 years old. A high percentage of the participants were single (86.6%). 62% were students. Pharmacy is the profession or field of study for most participants (83.4%). Half of the participants live in the city (51%). Most participants work at a local pharmacy. The majority (79.5%) have fewer than 5 years of experience. Most participants were well-informed about medication shortages and personally experienced the impact of this issue in their professional or personal lives. A shortage of baby supplies, specifically baby milk, was reported by 70.33% of the surveyed parents. Tablets and capsules are the pharmaceutical formulations that experience shortages most commonly. Shortages were reported in all categories of medications. Participants identified the shortage of raw materials and low profit margins as significant factors contributing to the occurrence of drug shortages. Further research into drug shortages in Syria is warranted to address this issue.

Keywords: Drug Shortage, Syria, Knowledge, Survey.
Scope of the Article: Pharmaceutical Analysis

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Volume-5 Issue-1, December 2024 – International Journal of Advanced Pharmaceutical Sciences and Research (IJAPSR)

B406605020225

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A406405011224

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A406305011224

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A406105011224

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A405905011224

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