Controlled Release of Doxorubicin, a Chemotherapy Medication using Papaya Enzyme ‘Papain’ Immobilized on ZIF-8
Benny Thomas1, Divya Mathew2
1Benny Thomas, Department of Chemistry, St Berchmans College, Changa Nassery, Kottayam, (Kerala), India.
2Divya Mathew, Department of Chemistry, St Berchmans College, Changa Nassery, Kottayam, (Kerala), India.
Manuscript received on 11 March 2024 | Revised Manuscript received on 27 March 2024 | Manuscript Accepted on 15 April 2024 | Manuscript published on 30 April 2024 | PP: 35-41 | Volume-4 Issue-3, April 2024 | Retrieval Number: 100.1/ijapsr.A4031124123 | DOI: 10.54105/ijapsr.A4031.04030424
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Abstract: An enzyme-mediated controlled drug delivery system is envisioned using a metal-organic framework (MOF). The pHdependent affinity of the enzyme towards the drug Doxorubicin is investigated. Doxorubicin is a chemotherapy medication for cancer treatment. Papain, a papaya enzyme belonging to the cysteine family, was chosen as the drug carrier for biomineralisation. Zeolitic imidazolate frameworks (ZIFs) are synthesised as the matrix for enzyme immobilisation. An encapsulation strategy was used for the immobilisation of both the enzyme and the drug into the carrier support. Encapsulation is envisioned as a one-pot synthesis. Both the systems DOX@ZIF-8 and DOX@Pap@ZIF-8 were found to be pH-sensitive for drug release. The DOX molecules are safely stored in the carrier matrix. Essentially no release of DOX was observed under physiological conditions. A papain-mediated drug delivery system is expected to be more specific and compelling in administering drugs at the right time and in the correct dose anywhere in the body than DOX@ZIF-8.
Keywords: Controlled Drug Release, Metal Organic Framework, Doxorubicin, ZIF-8, Papaya Enzyme, Papain, Enzyme Immobilization and Biomineralization.
Scope of the Article: Medicinal Chemistry