Triazine: A Scaffold with Never Ending Pharmacological Potential
Brijeshkunvar Mishra1, Richa Mishra2
1Brijeshkunvar Mishra, RB Science Research Lab, Bhopal (M.P.), India.
2Richa Mishra, Indira Institute of Professional Studies, Bhopal (M.P.), India.
Manuscript received on 25 December 2023 | Revised Manuscript received on 08 January 2023 | Manuscript Accepted on 15 April 2024 | Manuscript published on 30 April 2024 | PP: 20-34 | Volume-4 Issue-3, April 2024 | Retrieval Number: 100.1/ijapsr.E408405050825 | DOI: 10.54105/ijapsr.E4084.04030424
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© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Background: The triazine moiety occupies a unique position in medicinal chemistry due to its extensive biological and pharmacological potential. Over the decades, the moiety has been investigated for developing molecules that may be used to treat a plethora of pathological conditions, including inflammation, cancer, and infections. Several lead molecules have been developed from the triazine moiety. The fusion of triazine with other heterocyclic rings, such as imidazoles and pyrroles, has produced several bicyclic compounds with biological activity. The broad spectrum of activities displayed by triazines and the development of several commercial drugs containing triazines have led to growing interest among chemists worldwide in this moiety over the years. In this review, commercially available triazine molecules are presented, and an attempt has been made to compile the works reported by various researchers over the past decade, primarily related to the structural variations among triazine derivatives exhibiting antimicrobial, anticancer, and other biological activities. The objective of this review was to summarise recent reports on triazines and their analogues concerning their biological potential. Conclusion: The content of the review would help update researchers working towards the synthesis and design of new molecules for the treatment of several diseases, particularly those produced from the triazine scaffold.
Keywords: Triazine, Pharmacological Potential, Bioactivities.
Scope of the Article: Medical Physiology Pharmaceutical Chemistry