Permeation Enhancers for Transdermal Drug Delivery: Strategies and Advancements Focusing Macromolecules
Pratikeswar Panda1, Arpita Sahu2
1Pratikeswar Panda, Department of Pharmaceutics, Siksha ‘O’ Anusandhan University, Bhubaneswar (Odisha), India.
2Arpita Sahu, Department of Pharmaceutics, Siksha ‘O’ Anusandhan University, Bhubaneswar (Odisha), India.
Manuscript received on 05 September 2023 | Revised Manuscript received on 13 September 2023 | Manuscript Accepted on 15 October 2023 | Manuscript published on 30 October 2023 | PP: 1-11 | Volume-3 Issue-6, October 2023 | Retrieval Number: 100.1/ijapsr.F4028103623 | DOI: 10.54105/ijapsr.F4028.103623
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Abstract: The various transdermal drug delivery methods allow medications to cross the biological barriers and enter the bloodstream to elicit the desired pharmacological response. The relevant article focuses on the numerous biological and other macromolecule-based permeation enhancers, including carbohydrates, protein-peptides, and lipids, used in transdermal drug delivery. Although the focus of the study is on the role of macromolecules, as well as their mechanisms and modes of action for efficient transdermal drug delivery, it also concentrates on recent developments in various permeation enhancement techniques. Transdermal administration of weakly permeable medications with shorter biological half-lives typically utilises permeation augmentation techniques and agents, which should not have any explicit toxicological implications or incompatibility within the formulations. In this review, the limelight has been given to the promising permeation enhancers of the current scenario, which consist of various macromolecules.
Keywords: Permeation Enhancer, Macromolecules, Stratum Corneum, Enhancement Methods, Biomolecular Transdermal Delivery, Paracellular Pathway.
Scope of the Article: Pharmaceutics