A Comparative Study of Propofol-Based Total Intravenous Anaesthesia and Isoflurane-Based Inhalational Anaesthesia on Clinical Variables During Recovery from Anaesthesia
Abdulkahar Sayadi
Dr. Abdulkahar Sayadi, Faculty of Medicine, Idlib University, Idlib Syria.
Manuscript received on 25 June 2026 | First Revised Manuscript received on 18 July 2026 | Second Revised Manuscript received on 28 July 2026 | Manuscript Accepted on 15 August 2026 | Manuscript published on 30 August 2026 | PP: 1-7 | Volume-6 Issue-5, August 2026 | Retrieval Number: 100.1/ijapsr.E411606050826 | DOI: 10.54105/ijapsr.E4116.06050826
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© The Authors. Published by Lattice Science Publication (LSP). This is an open-access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: The process of recovery from general anaesthesia is much more than just a final step in surgical treatment – this is a densely medical period where various aspects such as pharmacology, airway protection, hemodynamics, patient comfort, and hospital performance are concentrated amid difficult conditions. In this paper, we present a comparative analysis of total intravenous anaesthesia with propofol (TIVA) and inhalational anaesthesia with isoflurane, paying particular attention to clinical parameters during the wake-up and recovery periods. The study involved 100 patients who underwent surgery and were randomly distributed into two groups. 50 people received anaesthesia based on propofol, while another 50 patients had anaesthesia based on isoflurane. The parameters studied included the time until the first response, eye opening, extubation, total recovery time, time in the post-anaesthesia care unit (PACU), changes in vital signs, postoperative nausea and vomiting (PONV), and postoperative shivering. According to the baseline characteristics, the two groups were comparable in many respects. Indicators of recovery in the case of propofol were better for all the studied periods: the first response was 7 ± 2 minutes in the propofol group compared to 15 ± 6 minutes in the isoflurane group; the eye opening was 8 ± 3 minutes compared to 18 ± 7 minutes; extubation was 6 ± 2 minutes compared to 12 ± 5 minutes; the total recovery period was 10 ± 4 minutes compared to 25 ± 8 minutes; PACU stay was 4 ± 3 minutes compared to 10 ± 6 minutes. The differences were significant (p < 0.05). The PONV and shivering were rarely observed in both groups and did not differ significantly. It can be concluded that TIVA with propofol might have advantages, including faster and easier recovery without additional risks.
Keywords: Propofol, Isoflurane, Total Intravenous Anaesthesia, Recovery from Anaesthesia, Postoperative Nausea and Vomiting, Postoperative Shivering.
Scope of the Article: Pharmacy Practice (pharmacist)